Potential Biochemical Properties of Endemic Onosma mutabilis

The Onosma L. (Lithospermae, Boraginaceae) genus contains many plant species with therapeutic properties due to its rich phytochemicals. mutabilis Boiss. & Hausskn. ex (O. mutabilis) is the for which there not enough information on characteristics. Objective: total phenolic content, antioxidant activity, possible bioactive compounds, and antibacterial activities of ethanolic extracts leaf, stem, root, flower parts endemic O. were investigated. Conclusions: content all was in range 9.2–31 mg gallic acid equivalent (GAE)/g extract. According results IC50 capacity values determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method between 4.39–29 μg/mL, while trolox activity cupric reducing (CUPRAC) 0.45–0.78 mmol equivalents (TE)/g Bioactive compounds have been analysed using gas chromatography coupled mass spectrometry (GC/MS) found contain 29 different chemical components. All tested showed effective against A. baumannii (ATCC 02026) (62.5 μg/mL MIC value) when compared reference drug Ampicillin (125 μg/mL).